CIPROXIFAN

CAS No.：184025-19-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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CIPROXIFAN Basic information

Product Name:	CIPROXIFAN
Synonyms:	Ciproxifan Moleate;FUB 359 Maleate;FUB359 Maleate;FUB-359 Maleate;Ciproxifan maleate, >=98%;Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;(4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;CIPROXIFAN
CAS:	184025-19-2
MF:	C16H18N2O2.C4H4O4
MW:	386.402
EINECS:
Product Categories:	Inhibitors
Mol File:	184025-19-2.mol

CIPROXIFAN Chemical Properties

solubility	DMSO: soluble32mg/mL
form	powder
color	white to beige

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38-43
Safety Statements	26-36/37/39
WGK Germany	3

MSDS Information

CIPROXIFAN Usage And Synthesis

Description	Ciproxifan is a histamine H₃ receptor antagonist (K_i = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H₃ over histamine H₁ and H₂, M₃ muscarinic, and α_1D- and β₁-adrenergic receptors (K_is = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT_1B, 5-HT_2A, 5-HT₃, and 5-HT₄ (K_is = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED₅₀ = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg.
Uses	Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.
Biochem/physiol Actions	Potent, selective H3 histamine receptor antagonist.

CIPROXIFAN Preparation Products And Raw materials

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