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| Propargyl-PEG2-acid Basic information |
| Product Name: | Propargyl-PEG2-acid | | Synonyms: | Propargyl-PEG2-acid;Propyne-PEG1-CH2CH2COOH;3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid;Propargyl-PEG1-COOH;CAS_1859379-85-3;3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid;Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]- | | CAS: | 1859379-85-3 | | MF: | C8H12O4 | | MW: | 172.18 | | EINECS: | | Product Categories: | | Mol File: | 1859379-85-3.mol |
| Propargyl-PEG2-acid Chemical Properties |
| Propargyl-PEG2-acid Usage And Synthesis |
| Description | Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage. | | Uses | Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Propargyl-PEG2-acid Preparation Products And Raw materials |
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