MAFP

CAS No.：188404-10-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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MAFP Basic information

Product Name:	MAFP
Synonyms:	5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID;MAFP;MAPF;METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE;METHYL ARACHIDONYL FLUOROPHOSPHONATE;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester
CAS:	188404-10-6
MF:	C21H36FO2P
MW:	370.48
EINECS:	201-185-2
Product Categories:	Cannabinoid receptor;Fatty Acid Derivatives & Lipids, inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:	188404-10-6.mol

MAFP Chemical Properties

RTECS	TA8108000
Fp	-16 °C
storage temp.	-70°C
form	methyl acetate solution
Sensitive	Air Sensitive

Safety Information

Hazard Codes	F,Xi
Risk Statements	11-36-66-67
Safety Statements	16-26-29-33
RIDADR	UN 1231 3/PG 2
WGK Germany	1

MSDS Information

Provider	Language
SigmaAldrich	English

MAFP Usage And Synthesis

Uses	(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.
Biological Activity	Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM).
Biochem/physiol Actions	MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor.

MAFP Preparation Products And Raw materials

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