Boc-12-Ado-OH

Boc-12-Ado-OH
  • CAS No.:18934-81-1

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :
BOC-12-ADO-OH Basic information
Product Name:BOC-12-ADO-OH
Synonyms:12-(BOC-AMINO)DODECANOIC ACID;BOC-12-ADO-OH;BOC-12-AMINODODECANOIC ACID;BOC-12-AMINOLAURIC ACID;BOC-NH-(CH2)11-COOH;N-TERT-BUTYLOXYCARBONYL-12-AMINO-DODECANOIC ACID;T-BUTOXYCARBONYL-12-AMINODODECANOIC ACID;T-BUTOXYCARBONYL-12-AMINOLAURIC ACID
CAS:18934-81-1
MF:C17H33NO4
MW:315.45
EINECS:
Product Categories:Amino Acids
Mol File:18934-81-1.mol
BOC-12-ADO-OH Chemical Properties
Melting point 83.5-84.5 °C
Boiling point 454.5±18.0 °C(Predicted)
density 0.997±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka4.78±0.10(Predicted)
BRN 1980302
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
BOC-12-ADO-OH Usage And Synthesis
DescriptionBoc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
BOC-12-ADO-OH Preparation Products And Raw materials
Raw materialsN-Boc-12-amino Dodecanoic Acid Methyl Ester-->12-AMINODODECANOIC ACID-->Di-tert-butyl dicarbonate

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