Boc-12-Ado-OH

Boc-12-Ado-OH
  • CAS No.:18934-81-1
Other grades of this product :
BOC-12-ADO-OH Basic information
Product Name:BOC-12-ADO-OH
Synonyms:12-(BOC-AMINO)DODECANOIC ACID;BOC-12-ADO-OH;BOC-12-AMINODODECANOIC ACID;BOC-12-AMINOLAURIC ACID;BOC-NH-(CH2)11-COOH;N-TERT-BUTYLOXYCARBONYL-12-AMINO-DODECANOIC ACID;T-BUTOXYCARBONYL-12-AMINODODECANOIC ACID;T-BUTOXYCARBONYL-12-AMINOLAURIC ACID
CAS:18934-81-1
MF:C17H33NO4
MW:315.45
EINECS:
Product Categories:Amino Acids
Mol File:18934-81-1.mol
BOC-12-ADO-OH Chemical Properties
Melting point 83.5-84.5 °C
Boiling point 454.5±18.0 °C(Predicted)
density 0.997±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka4.78±0.10(Predicted)
BRN 1980302
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
BOC-12-ADO-OH Usage And Synthesis
DescriptionBoc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
BOC-12-ADO-OH Preparation Products And Raw materials
Raw materialsN-Boc-12-amino Dodecanoic Acid Methyl Ester-->12-AMINODODECANOIC ACID-->Di-tert-butyl dicarbonate

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