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| Exendin-3 (9-39) amide Basic information |
| Exendin-3 (9-39) amide Chemical Properties |
| density | 1.51 | | RTECS | LF2460000 | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | form | Solid | | Water Solubility | Soluble in water at 1mg/ml | | InChIKey | WSEVKKHALHSUMB-UHFFFAOYSA-N |
| Exendin-3 (9-39) amide Usage And Synthesis |
| Description | Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats. | | Uses | Biological probe. | | Uses | Exendin-3 (9-39) is a potent and selective GLP-1 receptor antagonist. | | General Description | Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin. | | Biochem/physiol Actions | GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4. |
| Exendin-3 (9-39) amide Preparation Products And Raw materials |
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