Other grades of this product :
| SC 19220 Basic information |
| Product Name: | SC 19220 | | Synonyms: | 8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10[11H]-CARBOXY-(2-ACETYL)HYDRAZIDE;8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE;8-CHLORO-DIBENZO[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE;SC 19220;2-acetylhydrazide 10(11h)-carboxylic acid;2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid;8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacid,2-acetylhydrazide;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid | | CAS: | 19395-87-0 | | MF: | C16H14ClN3O3 | | MW: | 331.75 | | EINECS: | | Product Categories: | | Mol File: | 19395-87-0.mol |
| SC 19220 Chemical Properties |
| Melting point | 190-191 °C (lit.) | | storage temp. | Store at RT | | solubility | DMSO: 10 mg/mL, soluble | | form | solid | | color | white |
| SC 19220 Usage And Synthesis |
| Uses | SC 19220 is a selective EP1?receptor antagonist. | | Uses | SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures. | | Biological Activity | Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells). | | Biochem/physiol Actions | SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6. |
| SC 19220 Preparation Products And Raw materials |
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