Other grades of this product :
| Product Name: | MJ 33 | | Synonyms: | Phosphoric acid, mono[1-[(hexadecyloxy)methyl]-2-(2,2,2-trifluoroethoxy)ethyl] mono(hydroxymethyl) ester;MJ33-OH | | CAS: | 199106-13-3 | | MF: | C22H44F3O7P | | MW: | 508.55 | | EINECS: | | Product Categories: | | Mol File: | 199106-13-3.mol |
| MJ 33 Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: ≥5mg/mL (warmed at 60 °C) | | form | solid | | color | white to beige |
| MJ 33 Usage And Synthesis |
| Uses | MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor: - to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
- to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
- to study its potential use as a therapeutic agent
| | Biochem/physiol Actions | MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate. |
| MJ 33 Preparation Products And Raw materials |
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