Other grades of this product :
| ALX 5407 Hydrochloride Basic information |
| ALX 5407 Hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ~16 mg/mL, soluble | | form | solid | | color | off-white |
| ALX 5407 Hydrochloride Usage And Synthesis |
| Uses | ALX 5407 Hydrochloride can be used in the preparation of amino acid derivatives as pharmaceuticals for treatment of neurological and neuropsychiatric disorders.
| | Uses | ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function. | | Biochem/physiol Actions | ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM). | | references | [1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20. |
| ALX 5407 Hydrochloride Preparation Products And Raw materials |
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