NF 279

CAS No.：202983-32-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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NF 279 Basic information

Product Name:	NF 279
Synonyms:	NF 279;8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA;8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT;NF279 - CAS 202983-32-2 - Calbiochem;CS-319;8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid
CAS:	202983-32-2
MF:	C49H30N6Na6O23S6
MW:	1401.12
EINECS:	604-604-1
Product Categories:	Purinergics P2 receptor
Mol File:	202983-32-2.mol

NF 279 Chemical Properties

storage temp.	Desiccate at -20°C
form	White solid

Safety Information

MSDS Information

NF 279 Usage And Synthesis

Uses	NF 279 is a potent and selective P2X1 antagonist.
General Description	A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/K_B ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α_1A adrenoceptors, adenosine A₁ and A_2B receptors, histamine H₁, muscarinic M₃ and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X₁ >P2X₂ >P2X₃ >P2X₄ (IC₅₀ = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X₁ > human P2X₁ ? rat P2X₂ > rat P2X₃ ~human P2X₇ ? human P2X₄. Not degraded by ecto-nucleotidases.
Biological Activity	A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.
Biochem/physiol Actions	Cell permeable: yes

NF 279 Preparation Products And Raw materials

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