Other grades of this product :
| N-METHYLISATIN Basic information |
| N-METHYLISATIN Chemical Properties |
| Melting point | 130-133 °C (lit.) | | Boiling point | 287.44°C (rough estimate) | | density | 1.314 | | refractive index | 1.5050 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -2.41±0.20(Predicted) | | form | Crystalline Powder | | color | Orange to brownish | | Water Solubility | Insoluble in water. | | λmax | 427nm(CH2Cl2)(lit.) | | BRN | 128280 | | CAS DataBase Reference | 2058-74-4(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25-37/38-41 | | Safety Statements | 26-39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | NL7939000 | | HazardClass | IRRITANT | | HS Code | 29337900 |
| N-METHYLISATIN Usage And Synthesis |
| Chemical Properties | ORANGE TO BROWNISH CRYSTALLINE POWDER | | Uses | 1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents. | | Uses | - Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
- Reactant for regioselective preparation of spirocyclic oxindole-butenolides
- Reactant for synthesis of spiro-oxindoles
- Reactant for preparation of unsymmetrical oxindoles
- Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
- Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents
| | Synthesis Reference(s) | Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s | | General Description | The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations. |
| N-METHYLISATIN Preparation Products And Raw materials |
| Raw materials | 2-Butynamide, N-methyl-N-phenyl--->2-Propynamide, N-methyl-N-phenyl--->2-Propenamide,N-methyl-N,3-diphenyl--->Acetamide, N-methyl-2-(methylphenylamino)--->2-Propynamide, N-methyl-N,3-diphenyl--->1-Methylindoline-->4-Acetylbenzoic acid-->1-METHYL-2-INDOLINONE-->Ethanone, 1-[2-(methylamino)phenyl]- (9CI)-->Isatin-->1-benzyl-5-iodoindoline-2,3-dione-->5-iodo-1-methylindoline-2,3-dione | | Preparation Products | 2-Thiophenecarboxylic acid |
|
日本语
한국어
Français
Deutsch
España
Türkiye