Other grades of this product :
| 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Basic information |
| 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in ethanol at 20mg/ml | | form | powder | | color | white | | BRN | 7693643 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Usage And Synthesis |
| Description | ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable. | | Uses | Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. | | Uses | ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome. | | References | 1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195
2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421 |
| 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE Preparation Products And Raw materials |
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