4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&

CAS No.：207233-90-7

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4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU& Basic information

Product Name:	4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
Synonyms:	4,4''-DIISOTHIOCYANATOSTILBENE-2,2''-DISULPHONIC ACID DISODIUM SALT;4,4μ-Diisothiocyanato-2,2μ-stilbenedisulfonic acid hydrate disodium salt;4,4μ-Diisothiocyanatostilbene-2,2μ-disulfonic acid hydrate disodium salt;DIDS, Disodium 4,4μ-diisothiocyanatostilbene-2,2μ-disulfonate;4,4'-Diisothiocyanatostilbene-2,2'-disulphonic acid disodium salt hydrate;Disodium 4,4'-diisothiocyanato-2,2'-stilbenedisulphonate hydrate;DisodiuM 4,4'-diisothiocyanatostilbene-2,2'-disulfonate, 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodiuM salt hydrate;Disodium 4,4′-diisothiocyanatostilbene-2,2′-disulfonate
CAS:	207233-90-7
MF:	C16H8N2O6S4.2Na
MW:	498.491
EINECS:
Product Categories:	homoXlink
Mol File:	207233-90-7.mol

4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU& Chemical Properties

storage temp.	2-8°C
solubility	0.1 M potassium bicarbonate: soluble50mg/mL
form	powder
color	yellow
BRN	8179433

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-42
Safety Statements	22-26
WGK Germany	3
HS Code	29309090

MSDS Information

4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU& Usage And Synthesis

Uses

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt hydrate has been used:

as band3 protein inhibitor in rabbits(19)
for the inhibition of bicarbonate transporters in brain slice tissue(20)
as HCO3-/Cl- exchanger (anion exchanger) in embryos(21)

Biochem/physiol Actions

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is an anionic alkylating agent containing isothiocyanate residue. It is a negatively charged homobifunctional cross-linking reagent. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is a specific inhibitor of cellular anion permeability used in cell transport studies. The isothiocyanate groups react with primary amines at pH 9.0-10.0. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid alkylates lysine residues and inhibits apoptosis indirectly by targeting membrane based anion transporters.In addition, it also inhibits calcium transport in vesicles.

4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU& Preparation Products And Raw materials

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