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| QRX 431 Basic information |
| Product Name: | QRX 431 | | Synonyms: | GC-1; QRX-431;2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid;GC-1 (Sobetirome);Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22;[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid;QRX 431;GC-1;SobetiroMe | | CAS: | 211110-63-3 | | MF: | C20H24O4 | | MW: | 328.4 | | EINECS: | | Product Categories: | | Mol File: | 211110-63-3.mol |
| QRX 431 Chemical Properties |
| Melting point | 122 - 124°C | | Boiling point | 510.2±45.0 °C(Predicted) | | density | 1.152±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 3.22±0.10(Predicted) | | form | powder | | color | white to beige | | InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| QRX 431 Usage And Synthesis |
| Uses | GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist. | | Biological Activity | sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i | | Biochem/physiol Actions | Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans. | | references | 1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9. |
| QRX 431 Preparation Products And Raw materials |
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