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| Pomalidomide-PEG5-CO2H Basic information |
| Product Name: | Pomalidomide-PEG5-CO2H | | Synonyms: | POMALIDOMIDE-PEG 5-CO 2 H;Pomalidomide-PEG5-CO2H;Propanoic acid, 3-[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]oxy]-;Pomalidomide-PEG5-CO2H >=98%;Pomalidomide-PEG5-COOH;Pomalidomide-PEG5-CO2H ISO 9001：2015 REACH;Pomalidomide 4'-PEG5-acid;1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid | | CAS: | 2139348-63-1 | | MF: | C26H35N3O11 | | MW: | 565.57 | | EINECS: | | Product Categories: | peg | | Mol File: | 2139348-63-1.mol |
| Pomalidomide-PEG5-CO2H Chemical Properties |
| Boiling point | 791.0±60.0 °C(Predicted) | | density | 1.360±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.28±0.10(Predicted) |
| Pomalidomide-PEG5-CO2H Usage And Synthesis |
| Uses | Protein degrader builiding block Pomalidomide-PEG5-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Pomalidomide-PEG5-CO2H Preparation Products And Raw materials |
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