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| HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Basic information |
| Product Name: | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | | Synonyms: | 2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-;2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-;2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso-;Brn 3981691;meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane;meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane;2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel-;ICRF-193 apoptosis inducer, arabinosidase substrate | | CAS: | 21416-88-6 | | MF: | C12H18N4O4 | | MW: | 282.3 | | EINECS: | | Product Categories: | | Mol File: | 21416-88-6.mol |
| HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Chemical Properties |
| density | 1.308 | | storage temp. | -20°C | | solubility | DMSO: soluble4mg/mL |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 36/37 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | TL6380200 |
| HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Usage And Synthesis |
| Uses | ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis. | | General Description | ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable?complex. | | Biochem/physiol Actions | ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks. |
| HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Preparation Products And Raw materials |
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