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| 1400 W DIHYDROCHLORIDE, 96 Basic information |
| 1400 W DIHYDROCHLORIDE, 96 Chemical Properties |
| Melting point | 208 °C | | storage temp. | -20°C | | solubility | Soluble in Water (up to 25 mg/ml). | | form | White solid | | color | White | | Stability: | Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day. |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29242998 |
| 1400 W DIHYDROCHLORIDE, 96 Usage And Synthesis |
| Description | 1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2 | | Chemical Properties | white to off-white powder | | Uses | A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM. | | Uses | 1400W dihydrochloride has been used:- as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
- as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
- to study its efficacy on renal ischemia/ reperfusion injury in rats
- as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation
| | General Description | A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS. | | Biochem/physiol Actions | Cell permeable: yes | | References | References/Citations
1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959
2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300
3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255 |
| 1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials |
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