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| PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE Basic information |
| Product Name: | PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE | | Synonyms: | PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE;Perfluorophenyl diphenylphosphinate;1-diphenylphosphoryloxy-2,3,4,5,6-pentafluorobenzene;Diphenylphosphinic acid pentafluorophenyl ester;perfluorophenyl diphenylphosphinate(FDPP);Phosphinic acid, P,P-diphenyl-, 2,3,4,5,6-pentafluorophenyl ester;FDPP | | CAS: | 138687-69-1 | | MF: | C18H10F5O2P | | MW: | 384.24 | | EINECS: | 1308068-626-2 | | Product Categories: | Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds | | Mol File: | 138687-69-1.mol |
| PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE Chemical Properties |
| Melting point | 47-50 °C (lit.) | | Boiling point | 413.1±55.0 °C(Predicted) | | density | 1.45 | | storage temp. | Sealed in dry,Room Temperature | | InChIKey | OOWSDKUFKGVADH-UHFFFAOYSA-N |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29319090 |
| PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE Usage And Synthesis |
| Chemical Properties | White to yellow solid | | Uses | Pentafluorophenyl Diphenylphosphinate is a reagent used as carboxyl activating group and a coupling agent in variety of amide bond formations. | | Uses | FDPP can be used as a coupling reagent in the: - Synthesis of peptides by solid-phase and solution-phase reactions.
- Preparation of macrocyclic peptide cyclotheonamide B as a thrombin inhibitor.
- Cyclooligomerization of N-methylated-L-valine thiazole amino acid to obtain its cyclic tetramers.
- Macrocyclization of an intermediate for the total synthesis of ziziphine N , and for the macrolactamization of precursor in synthesizing cryptophycin D.
| | General Description | Pentafluorophenyl diphenylphosphinate (FDPP) is a reagent, used as a coupling agent in the amide bond forming reactions without racemization. It can also be employed in the synthesis of dipeptides with high yields and good optical purity. FDPP can be prepared from diphenylphosphinic chloride and pentafluorophenol in the presence of imidazole. |
| PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE Preparation Products And Raw materials |
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