Other grades of this product :
| KDOAM-25 Basic information |
| Product Name: | KDOAM-25 | | Synonyms: | KDOAM-25;4-Pyridinecarboxamide, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-;KDOAM-25 trihydrochloride | | CAS: | 2230731-99-2 | | MF: | C15H25N5O2 | | MW: | 307.39 | | EINECS: | | Product Categories: | | Mol File: | 2230731-99-2.mol |
| KDOAM-25 Chemical Properties |
| KDOAM-25 Usage And Synthesis |
| Biochem/physiol Actions | KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells. |
| KDOAM-25 Preparation Products And Raw materials |
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