Other grades of this product :
| Phenanthridine Basic information |
| Product Name: | Phenanthridine | | Synonyms: | 3,4-Benzoisoquinoline;5-azaphenanthrene;6-Phenanthridine;9-Azaphenanthrene;PHENANTHRIDIN;PHENANTHRIDINE;3,4-BENZOQUINOLINE;BENZO[C]QUINOLINE | | CAS: | 229-87-8 | | MF: | C13H9N | | MW: | 179.22 | | EINECS: | 205-934-4 | | Product Categories: | | Mol File: | 229-87-8.mol |
| Phenanthridine Chemical Properties |
| Melting point | 104-107 °C (lit.) | | Boiling point | 349 °C/769 mmHg (lit.) | | density | 1.1255 (rough estimate) | | refractive index | 1.7270 (estimate) | | Fp | 100 °C | | solubility | phosphate buffer: soluble | | pka | 5.58(at 20℃) | | form | Powder | | color | White to beige | | Water Solubility | 0.3g/L(20 ºC) | | BRN | 120204 | | CAS DataBase Reference | 229-87-8(CAS DataBase Reference) | | EPA Substance Registry System | Phenanthridine (229-87-8) |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | SF7928000 | | HS Code | 29333990 | | Toxicity | mic-bac-sat 50 mg/plate 50NNAZ7,73,83 |
| Phenanthridine Usage And Synthesis |
| Chemical Properties | white to beige powder | | History | Phenanthridine was first discovered by Ame Pictet and H. J. Ankersmit in 1891 by pyrolysis of the condensed product of benzaldehyde and aniline. Earlier, phenanathridine and related compounds were prepared using mainly Pictect-Hurbert and modified Morgan-Walls type of condensation reactions. | | Uses | Phenanthridine is an isomeric compound of acridine. It is a nitrogen heterocycle that is the basis of DNA-binding fluorescent dyes through intercalation. Ethidium bromide and propidium iodide are the examples of such intercalating dyes. It is used as a dye in biological and chemical sensors. It is also used in the study of ecotoxicity and rotational spectroscopic investigations and radio astronomical searches. | | Definition | ChEBI: Phenanthridine is an azaarene that is the 9-aza derivative of phenanthrene. The parent of the class of phenanthridines. It is a mancude organic heterotricyclic parent, a polycyclic heteroarene, a member of phenanthridines and an azaarene. | | Preparation | Palladium catalyzed synthesis of phenanthridine has been accomplished by Pritchard and coworkers from imidoyl selenides. This was the first report of palladium insertion into the C-Se bond. The palladium insertion into the imidoyl selenides 3.20 followed by intramolecular cyclization and subsequent aromatization via the elimination of HSePh lead to the formation of substituted phenanthridines 3.21. Pd-catalysed synthesis of phenanathridine | | Synthesis Reference(s) | Journal of the American Chemical Society, 74, p. 6295, 1952 DOI: 10.1021/ja01144a521Journal of Heterocyclic Chemistry, 26, p. 865, 1989 DOI: 10.1002/jhet.5570260366Tetrahedron Letters, 29, p. 5463, 1988 DOI: 10.1016/S0040-4039(00)80787-X | | General Description | Phenanthridine appears as crystalline needles. Mutagenic. | | Air & Water Reactions | Sparingly soluble in water. | | Reactivity Profile | PHENANTHRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. | | Fire Hazard | Flash point data are not available for PHENANTHRIDINE, but is probably combustible. | | Safety Profile | Mutation data reported. When heated to decomposition it emits toxic vapors of NOx. |
| Phenanthridine Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye