Other grades of this product :
| Product Name: | L-AP4 | | Synonyms: | L-AP4;L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID;L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID;L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4);L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%;(2S)-2-Amino-4-phosphonobutyric acid;(S)-4-Phosphono-2-aminobutanoic acid;(S)-4-Phosphono-2-aminobutyric acid | | CAS: | 23052-81-5 | | MF: | C4H10NO5P | | MW: | 183.1 | | EINECS: | 200-258-5 | | Product Categories: | Glutamate receptor;Glutamate | | Mol File: | 23052-81-5.mol |
| L-AP4 Chemical Properties |
| Melting point | 207-215 °C | | Boiling point | 491.7±55.0 °C(Predicted) | | density | 1.628±0.06 g/cm3(Predicted) | | storage temp. | 0-6°C | | pka | 2.19±0.10(Predicted) | | form | solid | | Water Solubility | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH | | Sensitive | Light Sensitive | | CAS DataBase Reference | 23052-81-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | ES7191700 |
| L-AP4 Usage And Synthesis |
| Description | Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus. | | Chemical Properties | white to off-white crystalline powder | | Uses | Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus. | | Uses | L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist. | | Biological Activity | Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ . |
| L-AP4 Preparation Products And Raw materials |
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