(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
  • CAS No.:23788-74-1
Other grades of this product :
(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Basic information
Product Name:(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
Synonyms:p-Toluenesulfonic acid [(R)-2,2-dimethyl-1,3-dioxolane-4β-yl]methyl ester;p-Toluenesulfonic acid [R,(-)]-2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester;p-Toluenesulfonic acid [R,(-)]-2,2-dimethyl-1,3-dioxolane-4-ylmethyl ester;(R)-(-)-2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxolane-p-toluenesulfonate,97%;p-Toluenesulfonic acid ((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester;Toluene-4-sulfonic acid ((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)methyl ester;D-α,β-Isopropylideneglycerol-γ-tosylate;[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 4-methylbenzene-1-sulfonate
CAS:23788-74-1
MF:C13H18O5S
MW:286.34
EINECS:
Product Categories:chiral;Chiral Building Blocks;Dioxanes & Dioxolanes;Dioxolanes;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry
Mol File:23788-74-1.mol
(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Chemical Properties
Melting point 41-43 °C(lit.)
Boiling point 398.71°C (rough estimate)
density 1.208 g/mL at 25 °C(lit.)
refractive index n20/D 1.506(lit.)
Fp >230 °F
storage temp. -20°C
solubility Dichloromethane; Chloroform; Ethyl Acetate; Methanol; DMF;
form Oil
color Pale Brown
optical activity[α]/D 7.0±0.5°, neat
BRN 89800
InChIKeySRKDUHUULIWXFT-LLVKDONJSA-N
CAS DataBase Reference23788-74-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36-37/39
WGK Germany 3
10-21
HS Code 29329900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Usage And Synthesis
Chemical Propertiesclear yellow to light brown viscous liquid
Uses(R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.
(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Preparation Products And Raw materials
Preparation ProductsCis -Tosylate-->(S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE

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