| LEUPEPTIN HYDROCHLORIDE Basic information |
| Product Name: | LEUPEPTIN HYDROCHLORIDE |
| Synonyms: | ACETYL-LEU-LEU-ARG-AL HCL;ACETYL-LEU-LEU-ARG-AL HYDROCHLORIDE;LEUPEPTIN HYDROCHLORIDE;leupeptin hydrochloride from*microbial source;LEUPEPTIN HYDROCHLORIDE, HIGH PURITY;L-Leucinamide, N-acetyl-L-leucyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, monohydrochloride;Leupeptin hydrochloride >90%;(S)-2-acetaMido-N-((S)-1-(((S)-5-guanidino-1-oxopentan-2-yl)aMino)-4-Methyl-1-oxopentan-2-yl)-4-MethylpentanaMide hydrochloride |
| CAS: | 24125-16-4 |
| MF: | C20H39ClN6O4 |
| MW: | 463.01 |
| EINECS: | |
| Product Categories: | peptides;inhibitor;Miscellaneous Peptides;Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Enzyme Inhibitors;Enzymes;Inhibitors;L;Organic Building Blocks;Peptides and Proteins;Peptides for Cell Biology;Protease Inhibitors;Pepetides |
| Mol File: | 24125-16-4.mol |
| LEUPEPTIN HYDROCHLORIDE Chemical Properties |
| storage temp. | -20°C |
| Stability: | Stable, but store cold. Incompatible with strong bases, strong acids. |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2925290090 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| LEUPEPTIN HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | solid |
| Uses | Leupeptin Hydrochloride is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay. |
| Biochem/physiol Actions | Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.) |
| LEUPEPTIN HYDROCHLORIDE Preparation Products And Raw materials |
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