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| PHORBOL 12,13-DIACETATE Basic information |
| Product Name: | PHORBOL 12,13-DIACETATE | | Synonyms: | Phorbol 12,13-Diacetate >99%;(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl diacetate;PHORBOL 12,13-DIACETATE;PHORBOL 12,13-DIACETATE, 4BETA;PDA;5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-alpha,16-beta,4,4a,7a-alpha,7b,;8,9,9a-decahydro-4a-beta,7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethy;l)-1,1,6,8-alpha-tetramethyl-,9,9a-diacetate,(+) | | CAS: | 24928-15-2 | | MF: | C24H32O8 | | MW: | 448.51 | | EINECS: | | Product Categories: | Activator | | Mol File: | 24928-15-2.mol |
| PHORBOL 12,13-DIACETATE Chemical Properties |
| Boiling point | 477.23°C (rough estimate) | | density | 1.1793 (rough estimate) | | refractive index | 1.4480 (estimate) | | storage temp. | −20°C | | solubility | H2O: soluble | | form | powder | | color | white | | BRN | 2317312 |
| PHORBOL 12,13-DIACETATE Usage And Synthesis |
| Uses | Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins. | | General Description | Phorbol ester with enhanced hydrophilicity. | | Biochem/physiol Actions | Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK). |
| PHORBOL 12,13-DIACETATE Preparation Products And Raw materials |
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