Other grades of this product :
| R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Basic information |
| R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Chemical Properties |
| solubility | H2O: soluble6mg/mL | | form | solid | | color | white to off-white | | optical activity | [α]22/D +15.14°, c = 0.52 in DMF(lit.) |
| R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Usage And Synthesis |
| Uses | R(+)-SKF-81297 Hydrobromide is a dopamine D1 agonist. | | Uses | R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist: - to test it effect on the spike firing in rat retinal ganglion cells
- in human embryonic kidney (HEK) 293T cells
- to test its inhibitory effect in microglial cells
| | Biochem/physiol Actions | SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons. |
| R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE Preparation Products And Raw materials |
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