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| 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Basic information |
| Product Name: | 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE | | Synonyms: | I-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-(ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLYL)-IMIDAZOLE;1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-IMIDAZOLE;TRIM;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 98%;1-[2-(Trifluoromethyl)phenyl]-1H-imidazole98%;1-(2-Trifluoromethylphenyl)imidazole, 98+% | | CAS: | 25371-96-4 | | MF: | C10H7F3N2 | | MW: | 212.17 | | EINECS: | 636-734-9 | | Product Categories: | Imidazol&Benzimidazole | | Mol File: | 25371-96-4.mol |
| 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemical Properties |
| Melting point | 43 °C | | Boiling point | 75°C 0,02mm | | density | 1.3253 (estimate) | | Fp | 75°C/0.025mm | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml). | | form | White solid. | | pka | 4.96±0.10(Predicted) | | color | White | | Sensitive | Light Sensitive | | BRN | 3955637 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 25371-96-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | IRRITANT, LIGHT SENSITIVE | | HS Code | 29339900 |
| 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Usage And Synthesis |
| Description | TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2 | | Uses | TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models. | | Biological Activity | A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo . | | Biochem/physiol Actions | Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine. | | References | 1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349
2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423 |
| 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Preparation Products And Raw materials |
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