Other grades of this product :
| LL Z1640-2 Basic information |
| Product Name: | LL Z1640-2 | | Synonyms: | f 152 A1;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;C 292;FR148083;L 783279;TAK1 inhibitor 5ZO);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;5Z-7-Oxozeaenol >=98% (HPLC) | | CAS: | 253863-19-3 | | MF: | C19H22O7 | | MW: | 362.37 | | EINECS: | | Product Categories: | | Mol File: | 253863-19-3.mol |
| LL Z1640-2 Chemical Properties |
| Melting point | 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) | | Boiling point | 666.8±55.0 °C(Predicted) | | density | 1.270±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | powder | | pka | 7.32±0.70(Predicted) | | color | white to off-white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | WGK Germany | 3 | | HS Code | 3507909090 |
| LL Z1640-2 Usage And Synthesis |
| Uses | LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. | | Uses | (5Z)-7-Oxozeaenol is a highly potent inhibitor of TAK1, which is a member of the mitogen-acitvated kinase kinase kinase (MAPKKK) family. 5Z-?7-?Oxozeaenol blocked interleukin-?1-?induced activation of TAK1, JNK?/p38 MAPK, IκB kinases, and NF-?κB, resulting in inhibition of cyclooxgenase-?2 production. | | Biochem/physiol Actions | The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy. |
| LL Z1640-2 Preparation Products And Raw materials |
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