Other grades of this product :
| Adenylyl Imidodiphosphate Basic information |
| Product Name: | Adenylyl Imidodiphosphate | | Synonyms: | Adenylyl Imidodiphosphate;Adenosine 5'-[β,γ-imide]triphosphoric acid;AMP-P(NH)P;AMP-PNP;β,γ-ImidoATP;β,γ-Imido-ATP;5'-Adenylic acid, monoanhydride with imidodiphosphoric acid (8ci,9ci);Adenosine 5'-(beta,gamma-imidotriphosphate) | | CAS: | 25612-73-1 | | MF: | C10H17N6O12P3 | | MW: | 506.2 | | EINECS: | 277-127-5 | | Product Categories: | | Mol File: | 25612-73-1.mol |
| Adenylyl Imidodiphosphate Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble50mg/mL | | form | powder | | color | white | | BRN | 6047109 |
| Adenylyl Imidodiphosphate Usage And Synthesis |
| Uses | AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase. AMP-PNP has been used for two-motor fluorescence assay. | | Uses | Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide. | | General Description | AMP-PNP(adenylyl-imidodiphosphate) is an artificial substrate of enzyme, adenylate cyclase. Adenylate cyclase helps to hydrolyze adenylyl-imidodiphosphate slowly than ATP. | | Biochem/physiol Actions | A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels. |
| Adenylyl Imidodiphosphate Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye