2-Phenoxyaniline

CAS No.：2688-84-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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2-Phenoxyaniline Basic information

Product Name:	2-Phenoxyaniline
Synonyms:	AURORA KA-7802;2-AMINOPHENYL PHENYL ETHER;2-AMINODIPHENYL ETHER;2-PHENOXYANILINE;AKOS B020146;O-PHENOXYANILINE;2-Ade;2-phenoxy-anilin
CAS:	2688-84-8
MF:	C12H11NO
MW:	185.22
EINECS:	220-254-8
Product Categories:
Mol File:	2688-84-8.mol

2-Phenoxyaniline Chemical Properties

Melting point	47-49 °C(lit.)
Boiling point	170 °C18 mm Hg(lit.)
density	1.0936 (rough estimate)
refractive index	1.5300 (estimate)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Slightly soluble in chloroform and methanol.
form	Crystalline Powder or Flakes
pka	3.78±0.10(Predicted)
color	Brown to gray
BRN	777766
Stability:	Hygroscopic
CAS DataBase Reference	2688-84-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Aminodiphenyl ether(2688-84-8)
EPA Substance Registry System	o-Phenoxyaniline (2688-84-8)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/37/38-22
Safety Statements	26-37/39-36/37/39-36
RIDADR	2811
WGK Germany	3
RTECS	BY7940000
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29222990
Toxicity	LD50 ivn-mus: 212 mg/kg TXCYAC 8,347,77

MSDS Information

Provider	Language
2-Aminophenyl phenyl ether	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Phenoxyaniline Usage And Synthesis

Chemical Properties	Whitetolightyellowcrystalpowde
Uses	2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.
Uses	2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC₆H₄NHNa·NMe[(CH₂)₂NMe₂]₂. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.
General Description	2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.
Safety Profile	Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

2-Phenoxyaniline Preparation Products And Raw materials

Preparation Products

Triclosan-->4-Phenoxyaniline-->1-IODO-2-PHENOXY-BENZENE

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