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| 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Basic information |
| Product Name: | 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] | | Synonyms: | 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER];4-butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedio;4-butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedionehydrogensuccinate;ae-17;alfide;SUXIBUZONE;Acetanilide Impurity 1;butanedioicacid,mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl | | CAS: | 27470-51-5 | | MF: | C24H26N2O6 | | MW: | 438.47 | | EINECS: | 248-477-6 | | Product Categories: | DANILON | | Mol File: | 27470-51-5.mol |
| 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Chemical Properties |
| Melting point | 126-127° | | Boiling point | 550.33°C (rough estimate) | | density | 1.2847 (rough estimate) | | refractive index | 1.6300 (estimate) | | storage temp. | 2-8°C | | solubility | Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent), practically insoluble in cyclohexane. | | form | neat | | pka | 4.33±0.17(Predicted) | | color | White to Off-White | | CAS DataBase Reference | 27470-51-5 |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | WM9640000 | | Toxicity | LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973) |
| 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | analgesic, antipyretic, antiinflammatory | | Uses | Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone. It is a drug used for joint and muscular pain. | | Definition | ChEBI: A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses. | | Brand name | Calibene;Danalon om;Danilon;Flamilon;Flofos. | | World Health Organization (WHO) | Suxibuzone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1974 for the treatment of
rheumatic disorders. As it is structurally related to phenylbutazone, it is subjected
to rigorously restricted indications by some national regulatory authorities. See
WHO comment for phenylbutazone. | | Biochem/physiol Actions | A prodrug of phenylbutazone. |
| 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Preparation Products And Raw materials |
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![4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]](/img/27470-51-5.jpg "4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]")
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