5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

CAS No.：2882-15-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Basic information

Product Name:	5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
Synonyms:	5-METHOXY-2-METHYL INDOLE ACETIC ACID;Indomethacin impurity 1/5-methoxy-2-methyl-1H-Indole-3-acetic acid;Indomethacin EP Impurity B;Indometacin Impurit Ⅰ:5-Methoxy-2-Methyl-3-IndoleaceticAcid;Indomethacin USP RC A;5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID;(5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID;5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
CAS:	2882-15-7
MF:	C12H13NO3
MW:	219.24
EINECS:	220-734-7
Product Categories:	Heterocycles;Indole Derivatives;Heterocyclic Compounds;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Indoles and derivatives;Building Blocks;Heterocyclic Building Blocks;Indoles
Mol File:	2882-15-7.mol

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Chemical Properties

Melting point	161-163 °C (lit.)
Boiling point	360.05°C (rough estimate)
density	1.1825 (rough estimate)
refractive index	1.5270 (estimate)
storage temp.	2-8°C
solubility	methanol: soluble
pka	4.22±0.30(Predicted)
form	Crystalline Powder
color	Off-white to light yellow or light beige
CAS DataBase Reference	2882-15-7(CAS DataBase Reference)

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29349990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Usage And Synthesis

Chemical Properties	slightly yellow fine crystalline powder
Uses	A metabolite of Indomethacin.
Uses	Reactant for preparation of antimalarial agents Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents Reactant for preparation of histone deacetylase inhibitors Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor Reactant for preparation of prostaglandin D2 receptor antagonist
Uses	5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.
General Description	5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Preparation Products And Raw materials

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