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| Dihydroxythiobinupharidine Basic information |
| Product Name: | Dihydroxythiobinupharidine | | Synonyms: | Dihydroxythiobinupharidine;6,6′-Dihydroxythiobinupharidine;Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene-4'(5'H),3''(4''H)-[2H]quinolizine]-4,4''-diol, 6,6''-di-3-furanyldodecahydro-9,9''-dimethyl-, (2'S,3''S,4S,4''R,6S,6''S,9R,9''R,9aS,9''aS)-;6,6'-Dihydroxythiobinupharidine >=95% (HPLC) | | CAS: | 30343-70-5 | | MF: | C30H42N2O4S | | MW: | 526.73 | | EINECS: | | Product Categories: | | Mol File: | 30343-70-5.mol |
| Dihydroxythiobinupharidine Chemical Properties |
| Boiling point | 667.3±55.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | form | powder | | pka | 13.42±0.70(Predicted) |
| Dihydroxythiobinupharidine Usage And Synthesis |
| General Description | 6,6′-Dihydroxythiobinupharidine is an active compound found in Nuphar lutea extract. It is a dimeric sesquiterpene thioalkaloid which presents multiple activities. | | Biochem/physiol Actions | 6,6′-Dihydroxythiobinupharidine inhibits NFκB activation, leading to an induction of apoptosis via cleavage of procaspase-9 and poly (ADP-ribose) polymerase (PARP). It was also found to act synergistically with cytotoxic drugs such as cisplatin and etoposide, enabling their cytotoxic effect at lower concentrations. 6,6′-Dihydroxythiobinupharidine was found to have cytotoxic activity at a concentration of ~10 μM on human leukemia cells (U937), mouse melanoma cells (B16F10), and human fibroblasts (HT1080).In addition, Nuphar lutea extract was effective against both Leishmania promastigote and amastigote forms (IC50?=?2?±?0.12?μg/mL; ID50?=?0.65?±?0.023?μg/mL; LD50?=?2.1?±?0.096?μg/mL, STI?=?3.23). A synergistic antileishmanial activity was demonstrated with the antileishmanial drug, paromomycin.Recently 6,6′-dihydroxythiobinupharidine was found to be active against MRSA and VRE strains with an MIC of 1-4?μg/mL. Inhibition of DNA topoisomerase?IV but not DNA gyrase in S.?aureus was suggested as the mechanism of action. 6,6′-Dihydroxythiobinupharidine was also shown to promote neutrophil effector bactericidal functions. |
| Dihydroxythiobinupharidine Preparation Products And Raw materials |
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