1-(2-Hydroxy-5-methylphenyl)ethanone

CAS No.：1450-72-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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1-(2-Hydroxy-5-methylphenyl)ethanone Basic information

Product Name:	1-(2-Hydroxy-5-methylphenyl)ethanone
Synonyms:	1-(2-hydroxy-5-methylphenyl)-ethanon;1-Hydroxy-2-acetyl-4-methylbenzene;2’-Hydroxy-5’-methylacetophenon;5’-Methyl-2’-hydroxyacetophenone;Acetophenone, 2'-hydroxy-5'-methyl-;Acetophenone,2’-hydroxy-5’-methyl-;Ethanone,1-(2-hydroxy-5-methylphenyl)-;o-Acetyl-p-cresol
CAS:	1450-72-2
MF:	C9H10O2
MW:	150.17
EINECS:	215-915-2
Product Categories:	Aromatic Acetophenones & Derivatives (substituted);C9;Carbonyl Compounds;Ketones
Mol File:	1450-72-2.mol

1-(2-Hydroxy-5-methylphenyl)ethanone Chemical Properties

Melting point	45-48 °C(lit.)
Boiling point	112-114°C 12mm
density	1.079
refractive index	1.5369 (estimate)
FEMA	4594 \| 2-HYDROXY-5-METHYLACETOPHENONE
Fp	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	10.46±0.18(Predicted)
color	Light orange to Yellow to Green
Water Solubility	Insoluble in water.
JECFA Number	2045
BRN	1364840
CAS DataBase Reference	1450-72-2(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(2-hydroxy-5-methylphenyl)-(1450-72-2)
EPA Substance Registry System	Ethanone, 1-(2-hydroxy-5-methylphenyl)- (1450-72-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
Hazard Note	Irritant
TSCA	Yes
HS Code	29147000

MSDS Information

Provider	Language
1-(2-Hydroxy-5-methylphenyl)ethanone	English
ACROS	English
SigmaAldrich	English
ALFA	English

1-(2-Hydroxy-5-methylphenyl)ethanone Usage And Synthesis

Chemical Properties	yellow crystalline powder
Uses	2'-Hydroxy-5'-methylacetophenone is used to produce 2-ethyl-4-methyl-phenol. It is used as an intermediate in organic synthesis.
Preparation	Obtained by treatment of methyl 4-hydroxy-6-methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (82%).

1-(2-Hydroxy-5-methylphenyl)ethanone Preparation Products And Raw materials

Raw materials	Diethyl ether-->Pyridine-->Aluminum chloride-->Acetyl chloride-->p-Cresol-->1-(2-METHOXY-5-METHYLPHENYL)ETHANONE-->NSC 46633-->3'-Methylacetophenone
Preparation Products	4-Methylcatechol-->4-HYDROXY-6-METHYLCOUMARIN-->2,5-Dimethylbenzoxazole

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