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| ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Basic information |
| Product Name: | ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate | | Synonyms: | ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;NMDI14;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester;NMDI14 >=97% (HPLC) | | CAS: | 307519-88-6 | | MF: | C21H25N3O4S | | MW: | 415.51 | | EINECS: | | Product Categories: | | Mol File: | 307519-88-6.mol |
| ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Chemical Properties |
| Boiling point | 658.8±55.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | powder | | pka | 13.42±0.40(Predicted) | | color | white to beige |
| ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Usage And Synthesis |
| Uses | NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:- to study its effects on differentiating cardiomyocytes
- to study its effects on zebrafish pdzk1 gene-knockout embryos
- to analyze its effects on the apoptosis of colorectal cancer cells
| | Biochem/physiol Actions | NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53. |
| ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Preparation Products And Raw materials |
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