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| Pyrazofurin Basic information |
| Pyrazofurin Chemical Properties |
| Boiling point | 584.4±50.0 °C(Predicted) | | density | 1.785±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | form | powder | | pka | 7.17±0.50(Predicted) | | color | white to light brown | | optical activity | [α]/D -49 to -39°, c = 0.5 in H2O |
| Pyrazofurin Usage And Synthesis |
| Uses | Geldanamycin (G304500) derivative. | | Definition | ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group. | | Biochem/physiol Actions | Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection. | | Enzyme inhibitor | This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase. |
| Pyrazofurin Preparation Products And Raw materials |
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