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| C2 CERAMIDE Basic information |
| C2 CERAMIDE Chemical Properties |
| Melting point | 93-96 °C | | Boiling point | 477.13°C (rough estimate) | | density | 1.0283 (rough estimate) | | refractive index | 1.5614 (estimate) | | storage temp. | −20°C | | solubility | DMSO: soluble | | form | powder | | pKa | 13.50±0.20(Predicted) | | color | white | | Stability: | Moisture Sensitive |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29241990 |
| C2 CERAMIDE Usage And Synthesis |
| Description | C2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation. | | Chemical Properties | White Crystalline Solid | | Uses | Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases | | Uses | A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2 | | Biological Activity | A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro . | | Biochem/physiol Actions | Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases. | | References | 1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734
2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475
3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63
4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]
5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] |
| C2 CERAMIDE Preparation Products And Raw materials |
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