| N-Acetyl-4-piperidone Basic information |
| Product Name: | N-Acetyl-4-piperidone |
| Synonyms: | N-ACETYL-4-PIPERIDONE;N-ACETYLPIPERIDIN-4-ONE;AKOS BBS-00004258;1-Acetyl-4-piperidinone;4-Piperidinone, 1-acetyl-;N-Acetylpiperidone;1-ACETYL-4-PIPERIDONE;1-Acetyl-4-oxopiperidine |
| CAS: | 32161-06-1 |
| MF: | C7H11NO2 |
| MW: | 141.17 |
| EINECS: | 250-937-6 |
| Product Categories: | PHARMACEUTICAL INTERMEDIATES;Building Blocks;Heterocyclic Building Blocks;Piperidones |
| Mol File: | 32161-06-1.mol |
| N-Acetyl-4-piperidone Chemical Properties |
| Boiling point | 218 °C(lit.) |
| density | 1.146 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Oily Liquid |
| pka | -0.72±0.20(Predicted) |
| Specific Gravity | 1.16 |
| color | Clear orange |
| Water Solubility | Soluble in water. Insoluble in acetic acid. |
| BRN | 116031 |
| CAS DataBase Reference | 32161-06-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Acetyl-4-piperidone(32161-06-1) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 23-24/25-36-26 |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29333990 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-Acetyl-4-piperidone | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| N-Acetyl-4-piperidone Usage And Synthesis |
| Chemical Properties | clear orange oily liquid |
| Uses | 1-Acetyl-4-piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs, and manufacture of fentanyl. |
| Purification Methods | Purify it by fractional distillaton through a short Vigreux column (15mm, p 11). The 2,4-dinitrophenylhydrazone has m 212-213o (from EtOH). It is freely soluble in H2O but insoluble in Et2O. [McElvain & McMahon J Am Chem Soc 71 901 1949, Beilstein 21/6 V 246.] |
| N-Acetyl-4-piperidone Preparation Products And Raw materials |
| Raw materials | 1,4-Dioxa-8-azaspiro[4.5]decane, 8-acetyl- (9CI)-->1,4-Dioxa-8-azaspiro[4.5]decane-->Acetyl chloride-->4-Piperidinone-->Acetic anhydride-->Acetylacetone-->4-oxopiperidinium chloride-->4,4-Piperidinediol hydrochloride |
| Preparation Products | 1-ACETYLPIPERIDIN-4-OL-->Methanol |
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