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| 4E1RCat Basic information |
| Product Name: | 4E1RCat | | Synonyms: | 4E1RCat;Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid;CS-1228 | | CAS: | 328998-25-0 | | MF: | C28H18N2O6 | | MW: | 478.45 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 328998-25-0.mol |
| 4E1RCat Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥5mg/mL | | form | powder | | color | brown to dark brown |
| 4E1RCat Usage And Synthesis |
| Description | 4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions. It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM. 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage. | | Uses | 4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts. | | Biochem/physiol Actions | 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc. |
| 4E1RCat Preparation Products And Raw materials |
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