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| SU 6656 Basic information |
| Product Name: | SU 6656 | | Synonyms: | SU6656 - CAS 330161-87-0 - Calbiochem;SU 6656;SU-6656;CS-1672;N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide;2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]- | | CAS: | 330161-87-0 | | MF: | C19H21N3O3S | | MW: | 371.45 | | EINECS: | | Product Categories: | | Mol File: | 330161-87-0.mol |
| SU 6656 Chemical Properties |
| density | 1.378±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: 12 mg/mL orange solution | | pka | 11.87±0.20(Predicted) | | form | powder | | color | orange-brown | | InChIKey | LOGJQOUIVKBFGH-YBEGLDIGSA-N |
| SU 6656 Usage And Synthesis |
| Description | The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer. | | Uses | The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.
| | Uses | SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death. | | General Description | A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 μM) and IGF-1 receptor kinase (IC50 ≥20 μM). | | Biochem/physiol Actions | Cell permeable: yes | | in vivo | su6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. it also facilitates tumor growth delay when administered during fractionated irradiation. [3] | | references | 1. blake ra, broome ma, liu x et al. su6656, a selective src family kinase inhibitor, used to probe growth factor signaling. mol cell biol. 2000 dec;20(23):9018-27.2. lannutti bj, blake n, gandhi mj et al. induction of polyploidization in leukemic cell lines and primary bone marrow by src kinase inhibitor su6656. blood. 2005 may 15;105(10):3875-8.3. cuneo kc, geng l, tan j et al. src family kinase inhibitor su6656 enhances antiangiogenic effect of irradiation. int j radiat oncol biol phys. 2006 mar 15;64(4):1197-203. |
| SU 6656 Preparation Products And Raw materials |
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