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(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

CAS No.：330676-02-3

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(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide Basic information

Product Name:	(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Synonyms:	(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide;KH 7;(E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N′-(5-bromo-2-hydroxybenzylidene)propanehydrazide;sAC inhibitor KH7;Propanoic acid, 2-(1H-benzimidazol-2-ylthio)-, 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
CAS:	330676-02-3
MF:	C17H15BrN4O2S
MW:	419.3
EINECS:
Product Categories:
Mol File:	330676-02-3.mol

(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide Chemical Properties

density	1.61±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	powder
pka	7.90±0.48(Predicted)

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII

MSDS Information

(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide Usage And Synthesis

Uses

KH7 has been used:

as a soluble adenyl?cyclase?(sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient? receptor type 1 (TRPV1) in sperm cells.
as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells.
as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).

Biochem/physiol Actions

KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling.

(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide Preparation Products And Raw materials

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