Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem

CAS No.：335166-00-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Basic information

Product Name:	Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
Synonyms:	Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
CAS:	335166-00-2
MF:	C19H21Br2ClFN3
MW:	505.65
EINECS:
Product Categories:
Mol File:	335166-00-2.mol

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Chemical Properties

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MSDS Information

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Usage And Synthesis

General Description

A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC₅₀ = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC₅₀ = 2.5 μM).

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Preparation Products And Raw materials

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