| Ethyl diethoxyphosphinylformate Basic information |
| Product Name: | Ethyl diethoxyphosphinylformate |
| Synonyms: | Diethyl carbethoxyphosphonate;Diethyl ethoxycarbonylphosphonate;Ethyl diethoxyphosphinecarboxylate oxide;Formic acid, phosphono-, triethyl ester;phosphinecarboxylicacid,diethoxy-,ethylester,oxide;Triethyl carboxyphosphonate;Triethyl phosphonomethanoate;(ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER |
| CAS: | 1474-78-8 |
| MF: | C7H15O5P |
| MW: | 210.16 |
| EINECS: | 216-016-8 |
| Product Categories: | Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds |
| Mol File: | 1474-78-8.mol |
| Ethyl diethoxyphosphinylformate Chemical Properties |
| Boiling point | 135 °C12 mm Hg(lit.) |
| density | 1.11 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | neat |
| Specific Gravity | 1.11 |
| color | Colorless to Almost colorless |
| BRN | 1781949 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 1474-78-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8) |
| EPA Substance Registry System | Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 24/25-36/37-26-37-24 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 2931 39 90 |
| MSDS Information |
| Provider | Language |
|---|---|
| Ethyl diethoxyphosphinylformate | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Ethyl diethoxyphosphinylformate Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid |
| Uses | Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral. |
| General Description | for synthesis |
| Purification Methods | Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.] |
| Ethyl diethoxyphosphinylformate Preparation Products And Raw materials |
| Preparation Products | Foscarnet sodium |
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