Product

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

CAS No.：1478-53-1

Other grades of this product :

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Basic information

Product Name:	DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
Synonyms:	DIETHYL (DIFLUOROMETHANE)PHOSPHONATE;DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER;diethyl(difluoromethyl)phosphonate;DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%;P-DifluoroMethylphosphonic Acid Diethyl Ester;1-[difluoromethyl(ethoxy)phosphoryl]oxyethane;Phosphonic acid,P-(difluoromethyl)-, diethyl ester;uoromethanephosphonate
CAS:	1478-53-1
MF:	C5H11F2O3P
MW:	188.11
EINECS:
Product Categories:	Inhibitors;Intermediates;Phosphorylating and Phosphitylating Agents
Mol File:	1478-53-1.mol

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties

Boiling point	96°C 15mm
density	1.193
refractive index	n20/D 1.388(lit.)
Fp	113 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Clear Colourless
Specific Gravity	1.193
InChIKey	VVFGLBKYBBUTRO-UHFFFAOYSA-N

Safety Information

Hazard Codes	Xi
Risk Statements	34
Safety Statements	26-36/37/39
RIDADR	3265
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Usage And Synthesis

Chemical Properties	Colourless Liquid
Uses	Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition.
Synthesis Reference(s)	Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials

Phosphonic acid, P-(difluoroiodomethyl)-, diethyl ester-->DIETHYL (DIFLUORO(TRIMETHYLSILYL)METHYL) -PHOSPHONATE, 96-->Bromomethylboronic acid, pinacol ester-->Diethyl bromodifluoromethanephosphonate-->2-Iodopyridine-->Difluorochloromethane-->Ethyl methacrylate-->DIETHYL PHOSPHATE-->Triethyl phosphite-->Diethyl phosphite-->Diethyl chlorophosphate-->(Difluoromethyl)trimethylsilane

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