DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

CAS No.：1478-53-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Basic information

Product Name:	DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
Synonyms:	DIETHYL (DIFLUOROMETHANE)PHOSPHONATE;DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER;diethyl(difluoromethyl)phosphonate;DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%;P-DifluoroMethylphosphonic Acid Diethyl Ester;1-[difluoromethyl(ethoxy)phosphoryl]oxyethane;Phosphonic acid,P-(difluoromethyl)-, diethyl ester;uoromethanephosphonate
CAS:	1478-53-1
MF:	C5H11F2O3P
MW:	188.11
EINECS:
Product Categories:	Inhibitors;Intermediates;Phosphorylating and Phosphitylating Agents
Mol File:	1478-53-1.mol

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties

Boiling point	96°C 15mm
density	1.193
refractive index	n20/D 1.388(lit.)
Fp	113 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Clear Colourless
Specific Gravity	1.193
InChIKey	VVFGLBKYBBUTRO-UHFFFAOYSA-N

Safety Information

Hazard Codes	Xi
Risk Statements	34
Safety Statements	26-36/37/39
RIDADR	3265
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

MSDS Information

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Usage And Synthesis

Chemical Properties	Colourless Liquid
Uses	Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition.
Synthesis Reference(s)	Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials

Phosphonic acid, P-(difluoroiodomethyl)-, diethyl ester-->DIETHYL (DIFLUORO(TRIMETHYLSILYL)METHYL) -PHOSPHONATE, 96-->Bromomethylboronic acid, pinacol ester-->Diethyl bromodifluoromethanephosphonate-->2-Iodopyridine-->Difluorochloromethane-->Ethyl methacrylate-->DIETHYL PHOSPHATE-->Triethyl phosphite-->Diethyl phosphite-->Diethyl chlorophosphate-->(Difluoromethyl)trimethylsilane

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