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| PDGFR Tyrosine Kinase Inhibitor V Basic information |
| PDGFR Tyrosine Kinase Inhibitor V Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white to brown |
| PDGFR Tyrosine Kinase Inhibitor V Usage And Synthesis |
| General Description | A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.). | | Biochem/physiol Actions | Cell permeable: yes |
| PDGFR Tyrosine Kinase Inhibitor V Preparation Products And Raw materials |
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