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| Z-LEU-LEU-GLU-AMC Basic information |
| Product Name: | Z-LEU-LEU-GLU-AMC | | Synonyms: | CBZ-LEU-LEU-GLU-AMC;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE;BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE);PROTEASOME SUBSTRATE II (FLUOROGENIC);Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN;Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLU-MCA | | CAS: | 348086-66-8 | | MF: | C35H44N4O9 | | MW: | 664.75 | | EINECS: | | Product Categories: | Proteasome substrate II. | | Mol File: | 348086-66-8.mol |
| Z-LEU-LEU-GLU-AMC Chemical Properties |
| Boiling point | 967.8±65.0 °C(Predicted) | | density | 1.253±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | solid | | pka | 4.43±0.10(Predicted) |
| Z-LEU-LEU-GLU-AMC Usage And Synthesis |
| Description | Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment. | | Uses | Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples. | | Uses | A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole | | General Description | Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity. | | Biochem/physiol Actions | Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome. |
| Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials |
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