Other grades of this product :
| 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Basic information |
| Product Name: | 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 | | Synonyms: | 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7;cholest-5-en-3,7α-diol-d7;CHOLEST-5-EN-3,7Α-DIOL-D7;7Α-HYDROXYCHOLESTEROL-D7;7alpha-hydroxycholesterol-d7;7α-hydroxy Cholesterol-d7;7α-Hydroxycholesterol-25?26?26?26?27?27?27-[d7];Cholesterol Impurity 37 | | CAS: | 349553-94-2 | | MF: | C26H37D7O2 | | MW: | 395.67 | | EINECS: | | Product Categories: | Hydroxycholesterol | | Mol File: | 349553-94-2.mol |
| 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Chemical Properties |
| 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Usage And Synthesis |
| Description | 7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; ) and chenodeoxycholic acid (CDCA; ). It is formed via the oxidation of cholesterol by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes. 7α-hydroxy Cholesterol (40 μM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs). It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 μg/ml. 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet. | | Uses | 7α-hydroxycholesterol-d7 has been used as an internal standard for cholesterol and oxysterol measurement by gas chromatography-mass spectrometry (GC/MS). | | General Description | 7α-hydroxycholesterol is an oxysterol synthesized by the oxidation of the side chain of cholesterol. It is the precursor of bile acid. |
| 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye