Other grades of this product :
| FHPI HCL Basic information |
| Product Name: | FHPI HCL | | Synonyms: | SB202190 HCL;SB 202190, HYDROCHLORIDE;FHPI HCL;4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-iMidazol-2-yl]phenol Monohydrochloride;4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate;4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate;SB 202190 monohydrochloride hydrate;4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE HCL | | CAS: | 350228-36-3 | | MF: | C20H15ClFN3O | | MW: | 367.8 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| FHPI HCL Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: ≥12mg/mL | | form | solid | | color | white to beige |
| FHPI HCL Usage And Synthesis |
| Uses | The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in high
er levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat. | | Uses | The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat. | | General Description | A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388). | | Biochem/physiol Actions | SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines. |
| FHPI HCL Preparation Products And Raw materials |
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