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| H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Basic information |
| H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties |
| Boiling point | 1143.1±65.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in H2O | | form | solid | | pka | 9.84±0.15(Predicted) | | Water Solubility | Soluble in water |
| H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Usage And Synthesis |
| Uses | AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation. | | Biological Activity | ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4]. | | references | [1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34. [4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85. |
| H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials |
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