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| Product Name: | Ani9 | | Synonyms: | Ani9;2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide;Acetic acid, 2-(4-chloro-2-methylphenoxy)-, 2-[(2-methoxyphenyl)methylene]hydrazide | | CAS: | 356102-14-2 | | MF: | C17H17ClN2O3 | | MW: | 332.78 | | EINECS: | | Product Categories: | | Mol File: | 356102-14-2.mol |
| density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | powder | | pka | 11.73±0.46(Predicted) | | color | white to beige |
| Description | Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM). It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner. | | Uses | Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules. | | Uses | (4-Chloro-2-methylphenoxy)-[(2-methoxyphenyl)methylene]hydrazide Acetic Acid inhibits anoctamin1/transmembrane protein 16A, a calcium-activated chloride channel involved in fluid secretion, smooth muscle contraction, nociception and cancer progression. | | Biochem/physiol Actions | 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma. |
| Ani9 Preparation Products And Raw materials |
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