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| COPROSTANOL Basic information |
| Product Name: | COPROSTANOL | | Synonyms: | 5BETA(H)-CHOLESTAN-3BETA-OL;5-BETA-CHOLESTANE-3-BETA-OL;5BETA-CHOLESTAN-3BETA-OL;(3-beta,5-beta)-cholestan-3-o;3beta-Hydroxy-5beta-cholestanol;3-beta-Hydroxycholestane;5beta-cholestanol;Cholestan-3-ol | | CAS: | 360-68-9 | | MF: | C27H48O | | MW: | 388.68 | | EINECS: | 206-638-8 | | Product Categories: | | Mol File: | 360-68-9.mol |
| COPROSTANOL Chemical Properties |
| Melting point | 101° | | alpha | D18 +28° (c = 1.8 in CHCl3) | | Boiling point | 454.32°C (rough estimate) | | density | 0.9506 (rough estimate) | | refractive index | 1.5250 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Ethylacetate (Slightly) | | form | Solid | | pka | 15.14±0.70(Predicted) | | color | White to Off-White | | EPA Substance Registry System | Coprosterol (360-68-9) |
| COPROSTANOL Usage And Synthesis |
| Uses | Coprostan-3-ol is a 27-carbon stanol resulted from biohydrogenation of cholesterol in the gut of most higher animals. It is a common biomarker for the presence of human faecal matter in the environment (1,2).This compound is a contaminant of emerging concern (CECs). | | Uses | It has been used as an internal standard for the determination of total amounts of cholesterol and 7-dehydrocholesterol reductase by GC/MS. | | General Description | Coprostan-3-ol is a cholesterol derivative that can be prepared from 5β-cholestan-3-one via reduction. | | Purification Methods | A possible impurity is the 3-ol from which it can be separated by chromatography on Al2O3 and eluting with Et2O/*C6H6 (1:24) whereby the 3-ol runs first (m 116-117o) and further elution gives the pure coprosterol (m 99-101o). Crystallise it from MeOH or aqueous EtOH. Its solubility is 0.79% in H2O at 25o. [Bridgewater & Shoppee J Chem Soc 1709 1953, Shoppee & Summers J Chem Soc 687 1950.] |
| COPROSTANOL Preparation Products And Raw materials |
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