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| 4BP-TQS Basic information |
| Product Name: | 4BP-TQS | | Synonyms: | 4BP-TQS;3H-Cyclopenta[c]quinoline-8-sulfonamide, 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-;4BP-TQS >=98% (HPLC) | | CAS: | 360791-49-7 | | MF: | C18H17BrN2O2S | | MW: | 405.31 | | EINECS: | | Product Categories: | | Mol File: | 360791-49-7.mol |
| 4BP-TQS Chemical Properties |
| Melting point | >202°C (dec.) | | Boiling point | 566.2±60.0 °C(Predicted) | | density | 1.505±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | powder | | pka | 10.21±0.40(Predicted) | | color | white to beige |
| 4BP-TQS Usage And Synthesis |
| Uses | 4BP-TQS is an agonist of human α7 nicotinic acetylcholine receptor (a7-nAChR), activates the channel via binding to an allosteric transmembrane site. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone. | | Biochem/physiol Actions | 4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone. |
| 4BP-TQS Preparation Products And Raw materials |
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